Gene Accession
P00519
Gene Alias
Protein names Recommended name Tyrosine-protein kinase ABL1 EC number EC:2.7.10.2 2 Publications (UniProtKB | ENZYME | Rhea) Alternative names Abelson murine leukemia viral oncogene homolog 1 Abelson tyrosine-protein kinase 1 Proto-oncogene c-Abl p150 Gene names Name ABL1 Synonyms ABL, JTK7
Background
ABL1 (F359V,F359C,F359I,Y253H,E255K,E255V) has been demonstrated to occur as a secondary resistance mutation in the context of BCR-ABL1. It confers clinical resistance to nilotinib.