Background

FOXD3 (Forkhead Box D3) is a Protein Coding gene. Diseases associated with FOXD3 include Autoimmune Disease 1 and Hashimoto Thyroiditis. Among its related pathways are Transcriptional regulation of pluripotent stem cells and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription cis-regulatory region binding. An important paralog of this gene is FOXD1. Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. ( FOXD3_HUMAN,Q9UJU5 )