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Rilonacept In Vitro Transcribed mRNA-LNP
SG-MRNA-LNP-1863
Rilonacept In Vitro Transcribed mRNA-LNP
Source：The ORF of Rilonacept was cloned in our IVT vector and mRNA was prepared through in vitro transcription and purification. The purified mRNA was further encapsulated with LNP(DSPC:Cholesterol:DMG-PEG:SM102).
Alternative Names：Rilonacept
Specification Sheet
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SKU：SG-MRNA-LNP-1863-DCPS
Product Name：Rilonacept In Vitro Transcribed mRNA-LNP(DSPC:Cholesterol:DMG-PEG:SM102)
Product Description：Rilonacept In Vitro Transcribed mRNA encapsulated with LNP(DSPC:Cholesterol:DMG-PEG:SM102)
SKU：SG-MRNA-LNP-1863-DCPS
Product Name：Rilonacept In Vitro Transcribed mRNA-LNP(DSPC:Cholesterol:DMG-PEG:SM102)
Product Description：Rilonacept In Vitro Transcribed mRNA encapsulated with LNP(DSPC:Cholesterol:DMG-PEG:SM102)
PROPERTIES
Cap:
m7GpppN
5'-UTR:
5' -untranslated region derived from human alpha-globin RNA with an optimized Kozak sequence
ORF:
IL-1RI/IL-1RacP ECD
3'-UTR:
3' UTR comprising two sequence elements derived from the aminoterminal enhancer of split (AES) mRNA and the mitochondrial encoded 12S ribosomal RNA
Poly(A) Tail:
A 110-nucleotide poly(A)-tail consisting of a stretch of 30 adenosine residues, followed by a 10-nucleotide linker sequence and another 70 adenosine residues.
Modifications:
N1-methyl-pseudouridine
Neutral Lipid:
1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)
Cholesterol:
Cholesterol
Lonizable Lipid:
1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (PEG2000-DMG)
PEG-lipid:
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)− 8-oxooctyl)amino)octanoate)(SM-102)
Storage:
-20 °C
Buffer:
PBS, pH7.4
Cryoprotectant:
Trehalose
Related Categories
mRNAs for Replacement Therapy Development
Background

Gene Alias

Rilonacept

Background

Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor.

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