Gene Accession

P0DTC6

Gene Alias

ORF6 protein (ORF6) (Accessory protein 6) (Non-structural protein 6) (ns6) (Protein X3)

Background

FUNCTION: Disrupts bidirectional nucleocytoplasmic transport by interacting with the host RAE1-NUP98 complex (PubMed:33360543, PubMed:33849972). Disrupts cell nuclear import complex formation by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane (PubMed:32979938). Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus (By similarity). Prevents STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities (PubMed:33097660). Suppresses IFN-beta production possibly by blocking IRF3 nuclear translocation (PubMed:32979938). Might induce accumulation of host HNRNPA1 (PubMed:33360543). {ECO:0000250|UniProtKB:P59634, ECO:0000269|PubMed:32979938, ECO:0000269|PubMed:33097660, ECO:0000269|PubMed:33360543, ECO:0000269|PubMed:33849972}.; FUNCTION: May play a role in viral double membrane vesicles networks to enhance viral replication. {ECO:0000269|PubMed:35187564}.