Gene Accession

P0DTC8

Gene Alias

ORF8 protein (ORF8) (Non-structural protein 8) (ns8)

Background

FUNCTION: Plays a role in modulating the host immune response (PubMed:31986261, PubMed:35343786). May act as a secreted virokine by mimicking interleukin-17A (IL17A), and thereby binding to the IL17RA receptor, leading to activation of the IL17 pathway and increased secretion of pro-inflammatory factors (PubMed:35343786). Contributes to the cytokine storm during SARS-CoV-2 infection (PubMed:33723527). May act by down-regulating major histocompability complex class I (MHC-I) at cell surface (PubMed:34021074, PubMed:35157849). May inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58 (PubMed:34177923). {ECO:0000269|PubMed:33723527, ECO:0000269|PubMed:34021074, ECO:0000269|PubMed:34177923, ECO:0000269|PubMed:35157849, ECO:0000269|PubMed:35343786, ECO:0000303|PubMed:31986261}.