Gene Accession

P0DTC4

Gene Alias

Envelope small membrane protein (E) (sM protein)

Background

FUNCTION: Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity). Regulates the localization of S protein at cis-Golgi, the place of virus budding (PubMed:33229438). May act by slowing down the cell secretory pathway (PubMed:33229438). May interfere with tight-junction stability by interacting with host MPP5. This would result in disruption of epithelial barriers, thereby amplifying inflammatory processes (PubMed:32891874). {ECO:0000255|HAMAP-Rule:MF_04204, ECO:0000269|PubMed:33229438, ECO:0000303|PubMed:32891874}.