Gene Accession

P0DTC9

Gene Alias

Nucleoprotein (N) (Nucleocapsid protein) (NC) (Protein N)

Background

FUNCTION: Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M (PubMed:33264373). Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (By similarity). {ECO:0000250|UniProtKB:P59595, ECO:0000255|HAMAP-Rule:MF_04096, ECO:0000269|PubMed:33264373}.; FUNCTION: May block host chemokine function in vivo, facilitating viral replication and transmission (PubMed:35921414). Acts by being secreted into the extracellular space where it competes to host chemokines for binding to host glycosaminoglycans (GAG) (PubMed:35921414). {ECO:0000269|PubMed:35921414}.; FUNCTION: May induce inflammasome responses in cultured cells and mice. Acts by interacting with host NLRP3 to facilitate inflammasome assembly, which induces cytokine release that may play a role in COVID lung injury. {ECO:0000269|PubMed:34341353}.