Seattle Genova is a leading company providing complete and comprehensive series of services on the liposome’s formation and its characterization. With the help of our scientist’s knowledge and years of experience, Seattle Genova offers in vitro drug release study services in the category of physical characterization of liposomes. We are here to serve our customers precise records with high quality services to share the burden of their research needs.
Although liposomal drug delivery systems are promising for the treatment of plethora of human diseases, however an unanticipated change in product quality or overall performance of such structures may also result in toxicity and/or change in-vivo efficacy, subsequently it's far critical to develop suitable in-vitro dissolution/ release testing strategies to ensure product quality, overall performance and to help in product development. In vitro release testing is typically used determining the most possible outcomes of in vivo behavior. Generally, in vitro release studies are executed at 37°C (physiological temperature), although in some examples, testing at increased temperatures has been performed to characterize drug release from liposomes.
Method
The most common method used for in vitro drug release study is dialysis method. The simple establishment of the DM is that drug from the dosage form diffuses swiftly from one compartment, through the membrane and enters the other compartment from where it is sampled for analysis. Thus, membranes with a sufficiently high membrane MWCO (molecular weight cut-off) are frequently selected for in-vitro drug release studies to overcome drug diffusion across membrane. If membrane is not sealed properly, leakage of media and drug may also arise from each ends of the dialysis bag set-up. Another issue to be taken into consideration is that this method cannot be used with drugs that bind to the dialysis membrane.
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