Adeno-associated virus (AAV) has been an increasingly important viral vector for gene therapy and cell therapy. At Seattle Genova, we offer the world-class capability and capacity to provide AAV packaging services for all projects. We have supplied major pharmaceutical companies and biopharma companies with a wide variety of vectors. At Seattle Genova, we use state-of-the-art equipment, time-tested techniques, and advanced design concepts to provide our viral vector development and manufacturing services.
Workflow of our services
1.AAV vector construction & production
2.Cell expansion, plasmid transfection & viral vector production
4.Fill & finish
Recommended AAV Serotypes
AAV1, AAV6, AAV8, AAV9
AAV8, AAV9, AAV-DJ
AAV5, AAV6, AAV9
Central Nervous System
AAV1, AAV5, AAV8, AAV9, AAV-DJ
AAV1, AAV2, AAV5, AAV8
AAV1, AAV8, AAV9
Analytics: contaminant and impurity QC testing
To help ensure regulatory approval of the final AAV product, QC testing must be implemented. We offer rapid molecular methods for contaminant and impurity testing across the AAV production workflow.
Titering (by digital droplet PCR)
Sterility and mycoplasma testing
Purity by Sypro Ruby staining
In-vitro transduction (detected by fluorescent expression when applicable)
PCR-based confirmation of the viral genome
Full sequencing of the packaged viral genome by next generation sequencing
Residual host cell DNA testing of cell culture–based therapies
Quantitation of Sf-rhabdovirus in cell culture-based therapies
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