Custom Organoid Culture Service

Seattle Genova offers innovative organoids culture models, which are used in regenerative medicine. The organoid culture models we customized have fostered novel potential therapeutic applications. Moreover, our organoid cultures for disease modeling provide an innovative link between cell lines and in vivo studies. Hence, our organoid cultures for disease modeling provide great promise in translation research.

Research Background

Seattle Genova utilizes both PCS- (pluripotent stem cell-) and aSC (organ-restricted adult stem cell)-based organoids, to study the basic gene functions and cellular processes.

Our Service Portfolios

Following are the enumerated organoid disease models that we offer to provide innovative technologies 

Organoids of Brain Disease Models

Seattle Genova provides brain organoid models which can be utilized for multiple neurological developmental disorders.  For example, we offer brain organoids with upregulation of the forkhead box G1 (FoxG1) gene to inspect autism spectrum disorder (ASD). Microcephaly, seckel syndrome, macrocephaly, schizophrenia, rett syndrome, Sandhoff disease, and zika virus organoids are also customized under our services. 

Organoids of Inner Ear Disease Models

Seattle Genova provides congenital ear disease models which investigate the early onset of hearing loss through TMPRSS3 gene mutation. Moreover, we provide degeneration inner ear organoids to produce Matrigel suspension which measures the exact mechanism of TMPRSS3-related hearing loss in detail.

Organoids of Retinal Disease Models

Seattle Genova provides LCA (Leber Congenital Amaurosis)-retinal organoid models from iPSCs to form an optic cup structure and to research rare genetic eye diseases such as glaucoma and X-linked retinitis pigmentosa. The retinal disease models recapitulate the spatiotemporal differentiation of the retina and are proven effective models for understanding retinal development and diseases.

Organoids of Skin Disease Models

The in-vitro human skin organoid models provided by Seattle Genova investigate Systemic sclerosis, Inflammatory skin disease, and Atopic eczema. Moreover, these models will be useful for studying the mechanisms of hair follicle induction, inhibition, and modeling. 

Organoids of Cardiac Disease Models

The cardiac disease models offer Barth syndrome, dilated cardiomyopathy, and hypertrophic cardiomyopathy disease organoids derived from iPSC cells to customize the demands of customers.

Organoids of Kidney Disease Models

Seattle Genova has recently incorporated genome editing tools into patient iPSC-derived kidney organoids, with precise control of genetic background to study human kidney diseases. We offer organoids that can be used for Polycystic kidney disease, autosomal recessive polycystic kidney disease, congenital nephrotic syndrome, and nephronophthisis-related ciliopathy (NPHP-RC) analysis. 

Organoids of Lung Disease Models

Seattle Genova is inspired to innovate state-of-the-art models for lung diseases by recapitulating the interactions between host pulmonary cells, immune cells, the ECM, and invading pathogens.

Organoids of Liver Disease Models

Seattle Genova is devoted to generating precise models of the diseased liver for exploring treatment options such as fibrosis, steatosis, non-alcoholic liver disease or alcoholic liver disease, and so on.

Organoids of Pancreatic Disease Models

The organoids models for pancreatic disease offered by Seattle Genova can be used in many complicated disease models including diabetes mellitus (DM), CF, and pancreatic adenocarcinoma.

Organoids of Gastric Disease Models

Seattle Genova uses gastric disease organoid models for validating the established hypothesis and discovering new mechanisms like detecting the mechanism of action of Helicobacter pylori infections.

Organoids of Intestinal and Colon Disease Models

Seattle Genova provides intestinal organoids (IOs) extracted from different tissues to investigate Host-microbe interaction and Cryptosporidium.

Organoids for Immune Responses 

Seattle Genova introduced descriptions of organoid models that simulate tissue-specific responses to COVID-19.

Deliverables

By acting as accurate human disease models, organoids have paved the way for discoveries in human biology and have advanced medical care by providing a platform for drug screening. Seattle Genova devotes itself to addressing many gaps in detailed knowledge of human development and disease-related events.