Custom Protein Labeling With PEGS

Seattle Genova providing outstanding protein labeling with PEG services with high quality and best conjugation techniques according to customer’s desire. The conjugation of PEG with a protein has opened gates of several of applications in the field of medical treatments, diagnostics, therapy techniques, material science, cosmetic science, and other industrial applications. PEGylation is a biochemical amendment technique of bioactive molecules with polyethylene glycol (PEG), which lends numerous perfect properties to proteins taken into consideration for therapy or genetic modification of cells. However, PEGylation of proteins is a complicated technique and may be performed using multiple approaches that depends the nature of the protein and the desired application. 

Mechanism

Experts of Seattle Genova performs conjugation of PEG with protein through cross linking with the amine groups, thiol groups, carboxylate, hydroxyl, aldehyde and ketone. Although, PEGylation can be done by different ways, such as.

▪Linear Activated PEGs: are commonly used for PEGylation, bioconjugation, and crosslinking with amine groups.

▪Multi-arm PEG conjugation: (4-,6-,8-arm) can be cross-linked into hydrogels and scaffolds for drug delivery or tissue engineering.

▪Branched PEG conjugation: are typically used for PEGylation, as the branched structure may improve stability in vivo.

▪Heterobifunctional PEG conjugation: PEGs containing reactive ends, that may both have the same (homobifunctional PEG) or different (heterobifunctional PEG) reactive groups are beneficial for conjugation and crosslinking for hydrogels. 

Highlights

Seattle Genova has achieved high quality services to fulfill customer’s desire. Seattle Genova’s services for the custom protein labeling with PEG are listed as follows:

Workflow：

Deliverables

●Product is 1 mg up to several grams

●A complete QC report