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Seattle Genova provides mRNA purification, which otherwise presents challenges to their chemical structures and related functionalities. These impurities could be in the form of byproducts like short mRNA, dsRNA (double-stranded RNA), plasmid DNA template, and mRNA aggregates. Moreover, these impurities arise from the various sources of reagents and could implicate the end results of the research. Hence Seattle Genova provides extensive purification methods to attain maximum purity of mRNA.
Seattle Genvoa provides variable services for the retainment of purity and integrity of the mRNA. Moreover, the process related impurities can also be purified through various tecniques which are enlisted below.
Table 1 Purity and Integrity of mRNA
Characterisation | Services |
Size distribution | SEC (UV, RI, MALLS) / cGE (UV) |
Purity | Ion-exchange chromatography (UV), IP-RP-(U)HPLC (V) |
5' Capping efficiency | HPLC (UV, MS) |
3’ poly(A) tail length and percentage | HPLC (UV, MS) |
Residual dsRNA | ELISA, Dot Blot |
Table 2 Process Related Impurities
Characterisation | Services |
Residual DNA template | RT-qPCR |
Process contaminants | CE / GC (FID, MS) / HPLC (UV, MS) / ELISA / ICP (MS) |
Residual solvents | HS-GC (FID, MS) / (UHPLC (UV, MS) |
Elemental impurities | ICP (OES, MS) |
Microbiology | Bioburden / Sterility (filtration, direct inoculation) |
Seattle Genova have considerable experience on the analyses of biological complexes which have innovation the field of technology. Moreover, we provide the quality assistance which is continuously advancing to support the development of customized mRNA and related therapeutics. Hence our services provide compact and precise analysis of mRNA and complete profile of mRNA purity and impurity analysis.
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