Therapeutic proteins are medicines that are genetically engineered versions of naturally occurring human proteins. Seattle Genova has been the industry leader in mRNA-based replacement therapy development for our clients.
Based on their pharmacological activity, they can be divided into five groups:
(a) replacing a protein that is deficient or abnormal.
(b) augmenting an existing pathway.
(c) providing a novel function or activity.
(d) interfering with a molecule or organism.
(e) delivering other compounds or proteins, such as a radionuclide, cytotoxic drug, or effector proteins.
Therapeutic proteins can also be grouped based on their molecular types that include:
Fc fusion proteins
bone morphogenetic proteins
engineered protein scaffolds
They can also be classified based on their molecular mechanism of activity as:
(a) binding non-covalently to target, e.g., mAbs.
(b) affecting covalent bonds, e.g., enzymes.
(c) exerting activity without specific interactions, e.g., serum albumin.
Modified mRNA (modRNA) is a safe, non-immunogenic, efficient, transient, local, and controlled nucleic acid delivery system that can overcome the obstacles to some traditional approaches for cardiac gene delivery.
We have many years of experience providing advanced mRNA-based replacement therapy services to the pharmaceutical, biopharmaceutical, and biotechnology industries. At Seattle Genova, we are your true collaborative partners, helping create a scientific and operational roadmap that helps you meet your research, development, and commercial goals. We’re ready and able to help you synthesize and characterize your mRNA products in detail.
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