Organoids For Disease Modeling

Both PCS- (pluripotent stem cell-) and aSC (organ-restricted adult stem cell)-based organoids provide a new window—between cell lines and in vivo studies—to studying basic gene functions and cellular processes. In addition to this, organoid technology also holds great promise for translational research.

Our service portfolios

-Organoids of brain disease models

Currently, brain organoid models open up the prospect of answering many questions regarding different brain diseases and developmental disorders. For example, we provide brain organoids with upregulation of the forkhead box G1 (FoxG1) gene to inspect on autism spectrum disorder (ASD). Also, mlcrocephaly, seckel syndrome, macrocephaly, schizophrenia, rett syndrome, sandhoff disease and zika vius organoids can be found in our products.

-Organoids of inner ear disease models

Congenital and early-onset hearing loss which with the mutation of TMPRSS3 was reported in 2013. And in 2019 we obtained degeneration inner ear organoid to produce Matrigel suspension. The exact mechanism of TMPRSS3-related hearing loss can be investigated more detailed.

-Organoids of retinal disease models 

Retinal organoids can recapitulate the spatiotemporal differentiation of the retina and have proven as effective models for understanding retinal development and diseases. We offer LCA (Leber Congenital Amaurosis)-retinal organoid models from iPSCs to form an optic cup structure researching some rare genetic eye diseases such as glaucoma and X-linked retinitis pigmentosa. 

-Organoids of skin disease models

In vitro human skin organoid models are expected to be useful for studying the mechanisms of hair follicle induction, inhibition, and modeling. Systemic sclerosis, Inflammatory skin disease and Atopic eczema can be investigated via our organoids. 

-Organoids of cardiac disease models

3D cardiac organoids can help create new physiological models of cardiovascular diseases. We provide Barth syndrome, dilated cardiomyopathy and hypertrophic cardiomyopathy diseases organoids derived from iPSC cells to meet your needs.

-Organoids of kidney disease models

Our recent work has incorporated genome editing tools into patient iPSC-derived kidney organoids, thus providing a unique opportunity to study human kidney diseases with a precise control of the genetic background. We produce organoids which can be used for Polycystic kidney disease, autosomal recessive polycystic kidney disease, congenital nephrotic syndrome, nephronophthisis-related ciliopathy (NPHP-RC) analysis. 

-Organoids of lung disease models

Lung organoids represent state-of-the-art platforms to model lung diseases by recapitulating the interactions between host pulmonary cells, immune cells, the ECM, and invading pathogens.

-Organoids of liver disease models

Seattle Genova is devoted to generate accurate models of the diseased liver for exploring treatment options such as fibrosis, steatosis, non-alcoholic liver disease or alcoholic liver disease and so on.

-Organoids of pancreatic disease models

Our organoids can be used as many complicated disease models including diabetes mellitus (DM), CF, and pancreatic adenocarcinoma.

-Organoids of gastric disease models

Helicobacter pylori infection caused many digestive ulcer diseases affect the world’s population. Seattle Genova uses organoid models for validating the established hypothesis, and discovering new mechanisms.

-Organoids of intestinal and colon disease models

We have been developed intestinal organoids (IOs) from different sources to help our clients to investigate diseases including Host-microbe interaction and Cyptosporidium.

We have also included descriptions of organoid models that simulate tissue-specific responses to COVID-19. By acting as accurate human disease models, organoids have paved the way for discoveries in human biology and have advanced medical care by providing a platform for drug screening. Seattle Genova devotes to address many gaps for a detailed knowledge of human development and disease-related events.