Organoids For Regenerative Medicine Research

Seattle Genova offers multiple organoids technologies which are derived from primary tissues and induced pluripotent stem cells (iPSC). Moreover, our iPSC-derived organoids provide promise for the generation of future advanced therapeutic medicinal products for various organ repair and hold a promising position in the field of regenerative medicine. We believe to provide maximum accuracies of organoids to excel in the field of regenerative medicine.

Fig: Therapeutic Effectiveness of Cholangiocyte Organoids in Regenerative Medicine (Rodrigues and Banales 2021).

Seattle Genova Services

Seattle Genova technology of organoids has enabled the growth of primary epithelial cells in 3D conditions in combination with other cell types and applied to a wide variety of regenerative medicine.  

iPSC-Derived Organoids

Our revolutionary technology of iPSC-Derived Organoids has allowed the reprogramming of adult somatic cells and applications in the therapeutic arena for regenerative medicines. Moreover, now this technology is focusing on transplanting iPSC-derived autologous alveolar epithelial cells for future prognosis. Additionally, in the field of diabetes, the transplantation of iPSC-derived islet organoids is also a source of attraction for researchers as a potent source of regenerative medicine. 

Cancer Organoids 

In the field of cancer, Seattle Genova provides various tumor/cancer organoids which allow capturing genetic heterogeneity which will enable progression-related modifications in a given cancer. Moreover, these tumor organoids can also serve as in vitro drug screening tools and potential sources of regenerative medicine.

Inflammatory Bowel Disease (IBD) Organoids 

Our services for organoid-based regenerative medicine have the potential to promote mucosal healing in refractory inflammatory bowel disease (IBD) and improve long-term prognosis as well.  

Viral Infections Organoids

Our services provide advanced organoids which appear to be major experimental tools to determine the pathophysiology of viral infections. Our organoid models have successfully applied to the zika virus as well as to SARS-Cov-2 infections to evaluate their potential therapeutics and multiple approaches to vaccination. Organoids derived from iPSC are highly permissive to the induction of viruses. 

Biliary Injury Organoids

Seattle Genova offers cholangiocyte organoids that have potential effectiveness in the repairment of injured human biliary epithelium. 

Reference

Rodrigues, P. M., & Banales, J. M. (2021). Applications of organoids in regenerative medicine: a proof-of-concept for biliary injury. Nature Reviews Gastroenterology & Hepatology, 18(6), 371-372.