Polymer-lipid Hybrid Particle Production For mRNA Delivery

Equipped with a team of professional scientists, Seattle Genova is capable of providing specialized support in the design, production, and evaluation of mRNA formulation services. Our mRNA manufacturing template provides a robust workflow, while our Polymer-lipid hybrid particle production services ensure a high-quality and consistent supply. Lipid polymer hybrid nanoparticles (LPNs) are evolving as a promising class of biomaterials for RNA delivery, which integrate the physicochemical properties of both lipids and polymers.

Structure

The core and the shell materials may consist of extraordinary polymeric materials, oils, and steel oxides, organic and inorganic compound. These structures are composed of following major layers and components, given as follows:

1. The internal most layer consist of various polymers, organic and inorganic materials that act as a core material.

2. The second layer of those hybrid NPs is fabricated with the natural or derived lipid that impart the preferred pharmacokinetic properties to the DDS.

3. The third layer consists of both lipid or polymer-conjugate that assist in the functionalization or surface decoration of the NPs.

Mechanism

The mechanism of the arrangement in distinctive layers and their compilation with each other may want similarly investigation. However, distinctive mechanisms explored imply that the arrangement and fusion method are based on the technique of preparation.

In the two-step conventional technique, the layer might be due to formation of lipid by layer that get adhere to the core particle that followed through the mixing because of hydrophilic and hydrophobic interaction among the lipid and polymer component. 

However, in the single-step technique, the most investigated and discovered mechanism is the precipitation of the lipid component on the polymeric core material. Some more recent strategies may also involve the self-assembling of those structural components.

Highlights

Deliverables

A Polymer-lipid hybrid particle product.

A complete work report.