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mRNAs for Vaccine Development
mRNAs for Vaccine Development

mRNAs for Vaccine Development

mRNA vaccines have been authorized for emergency use much less than one year after the emergence of COVID-19, demonstrating the extremely good improvement pace of the mRNA platform technology. However, even as the versatility of the mRNA platform could permit for the global development of latest vaccines, constraints which includes restrained intellectual property (IP), excessive price of goods, raw material bottlenecks, and shortage of skilled workforce restriction access to mRNA vaccines in low- and middle-earnings countries. Here, Seattle Genova presents a perspective on the global state of mRNA vaccine development for infectious diseases, and the manufacturing capabilities needed to enable vaccine access to fight ongoing/future pandemic and epidemic threats.

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Gene Name
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Capsid protein C (Core protein)
DENV-1 (strain Singapore/S275/1990) (DENV-1) Capsid protein C (Core protein) Circular RNA
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SKU
Product_name
Product Description
VAC-RNA-062
DENV-1 (strain Singapore/S275/1990) (DENV-1) Capsid protein C (Core protein) Circular RNA
In Vitro Transcribed mRNA template encoding DENV-1 (strain Singapore/S275/1990) (DENV-1) Capsid protein C (Core protein) Circular RNAwas further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
VAC-RNA-062-LNP
DENV-1 (strain Singapore/S275/1990) (DENV-1) Capsid protein C (Core protein) Circular RNA-LNP
VAC-RNA-062 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
Capsid protein C (Core protein)
DENV-4(strain Thailand/0348/1991) (DENV-4) Capsid protein C (Core protein) Circular RNA
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SKU
Product_name
Product Description
VAC-RNA-063
DENV-4(strain Thailand/0348/1991) (DENV-4) Capsid protein C (Core protein) Circular RNA
In Vitro Transcribed mRNA template encoding DENV-4(strain Thailand/0348/1991) (DENV-4) Capsid protein C (Core protein) Circular RNAwas further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
VAC-RNA-063-LNP
DENV-4(strain Thailand/0348/1991) (DENV-4) Capsid protein C (Core protein) Circular RNA-LNP
VAC-RNA-063 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
Capsid protein C (Core protein)
DENV-4(strain Thailand/0476/1997) (DENV-4) Capsid protein C (Core protein) Circular RNA
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SKU
Product_name
Product Description
VAC-RNA-064
DENV-4(strain Thailand/0476/1997) (DENV-4) Capsid protein C (Core protein) Circular RNA
In Vitro Transcribed mRNA template encoding DENV-4(strain Thailand/0476/1997) (DENV-4) Capsid protein C (Core protein) Circular RNAwas further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
VAC-RNA-064-LNP
DENV-4(strain Thailand/0476/1997) (DENV-4) Capsid protein C (Core protein) Circular RNA-LNP
VAC-RNA-064 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
Capsid protein C (Core protein)
DENV-4(strain Philippines/H241/1956) (DENV-4) Capsid protein C (Core protein) Circular RNA
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SKU
Product_name
Product Description
VAC-RNA-065
DENV-4(strain Philippines/H241/1956) (DENV-4) Capsid protein C (Core protein) Circular RNA
In Vitro Transcribed mRNA template encoding DENV-4(strain Philippines/H241/1956) (DENV-4) Capsid protein C (Core protein) Circular RNAwas further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
VAC-RNA-065-LNP
DENV-4(strain Philippines/H241/1956) (DENV-4) Capsid protein C (Core protein) Circular RNA-LNP
VAC-RNA-065 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
Capsid protein C (Core protein)
DENV-3 (strain Singapore/8120/1995) (DENV-3) Capsid protein C (Core protein) Circular RNA
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SKU
Product_name
Product Description
VAC-RNA-066
DENV-3 (strain Singapore/8120/1995) (DENV-3) Capsid protein C (Core protein) Circular RNA
In Vitro Transcribed mRNA template encoding DENV-3 (strain Singapore/8120/1995) (DENV-3) Capsid protein C (Core protein) Circular RNAwas further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
VAC-RNA-066-LNP
DENV-3 (strain Singapore/8120/1995) (DENV-3) Capsid protein C (Core protein) Circular RNA-LNP
VAC-RNA-066 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
Capsid protein C (Core protein)
DENV-4(strain Singapore/8976/1995) (DENV-4) Capsid protein C (Core protein) Circular RNA
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SKU
Product_name
Product Description
VAC-RNA-067
DENV-4(strain Singapore/8976/1995) (DENV-4) Capsid protein C (Core protein) Circular RNA
In Vitro Transcribed mRNA template encoding DENV-4(strain Singapore/8976/1995) (DENV-4) Capsid protein C (Core protein) Circular RNAwas further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
VAC-RNA-067-LNP
DENV-4(strain Singapore/8976/1995) (DENV-4) Capsid protein C (Core protein) Circular RNA-LNP
VAC-RNA-067 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
pol
DENV-3 (strain Martinique/1243/1999) (DENV-3) pol Protein Circular RNA
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SKU
Product_name
Product Description
VAC-RNA-068
DENV-3 (strain Martinique/1243/1999) (DENV-3) pol Protein Circular RNA
In Vitro Transcribed mRNA template encoding DENV-3 (strain Martinique/1243/1999) (DENV-3) pol Protein Circular RNAwas further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
VAC-RNA-068-LNP
DENV-3 (strain Martinique/1243/1999) (DENV-3) pol Protein Circular RNA-LNP
VAC-RNA-068 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
pol
DENV-3 (strain Sri Lanka/1266/2000) (DENV-3) pol Protein Circular RNA
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SKU
Product_name
Product Description
VAC-RNA-069
DENV-3 (strain Sri Lanka/1266/2000) (DENV-3) pol Protein Circular RNA
In Vitro Transcribed mRNA template encoding DENV-3 (strain Sri Lanka/1266/2000) (DENV-3) pol Protein Circular RNAwas further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
VAC-RNA-069-LNP
DENV-3 (strain Sri Lanka/1266/2000) (DENV-3) pol Protein Circular RNA-LNP
VAC-RNA-069 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
Capsid protein C (Core protein)
DENV-3 (strain China/80-2/1980) (DENV-3) Capsid protein C (Core protein) Circular RNA
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SKU
Product_name
Product Description
VAC-RNA-070
DENV-3 (strain China/80-2/1980) (DENV-3) Capsid protein C (Core protein) Circular RNA
In Vitro Transcribed mRNA template encoding DENV-3 (strain China/80-2/1980) (DENV-3) Capsid protein C (Core protein) Circular RNAwas further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
VAC-RNA-070-LNP
DENV-3 (strain China/80-2/1980) (DENV-3) Capsid protein C (Core protein) Circular RNA-LNP
VAC-RNA-070 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
Capsid protein C (Core protein)
DENV-2 (strain Peru/IQT2913/1996) Capsid protein C (Core protein) Circular RNA
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SKU
Product_name
Product Description
VAC-RNA-071
DENV-2 (strain Peru/IQT2913/1996) Capsid protein C (Core protein) Circular RNA
In Vitro Transcribed mRNA template encoding DENV-2 (strain Peru/IQT2913/1996) Capsid protein C (Core protein) Circular RNAwas further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
VAC-RNA-071-LNP
DENV-2 (strain Peru/IQT2913/1996) Capsid protein C (Core protein) Circular RNA-LNP
VAC-RNA-071 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
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