Prostate Organoid Culture Service

Seattle Genova provides the strategy of 3D organoids for the generation of prostate organoids culture derived from various human and mouse prostate cells and from metastatic cancer lesions and circulating tumor cells. Our 3D prostate organoids provide a source of deep analysis and research of prostate-related cancers and a medium for fully grown in vivo prostate and related biology conditions, including homeostasis, tumorigenesis, and drug discovery. Hence, we offer prostate organoids as an emerging field and summarize the current application through disease modeling, tissue regeneration, and drug screening.

Seattle Genova Services

Seattle Genova services include prostate organoids incorporating several distinct cell populations and rapidly dividing stem cells, facilitating their turnover cycle.

Organoid Culture from Prostate Cancer Cell Lines

Seattle Genova offers prostate organoids that are derived from tumor cells. These organoids have the functioning of molecular and genetic changes and act as potent genomic markers of anti-cancer drug sensitivity. 

Organoid Culture from Patient-Derived PC Cells

Seattle Genova also provides patient-derived prostate organoids 3D culture systems. These organoids act like mini organ systems with important prostate features and screening of gene mutations. Moreover, these prostate organoids closely recapitulate the in vivo microenvironment and molecular and genetic signature of tissues or organs of origin and are capable of self-renewal and self-organization. Hence, our patient-derived prostate organoids provide the benefit of cancer-related studies, disease modeling, drug discovery, and personalized therapy. 

Organoids Derived from Pluripotent Stem Cells (PSCs)

Seattle Genova produces prostate organoids derived from human and mouse pluripotent stem cells. Pluripotent cells can imitate and transform into any type of tissue in the body, and their ability to replicate the working of the prostate. Hence, we utilize pluripotent stem cells to bioengineer various human organs and biologics.

Deliverables

Seattle Genova provided advances in the development of organoids that have thrilling possibilities for Proste cancer studies. Establishing organoid biobanks and patient-derived organoids can promote personalized medicine, for example, a high-throughput drug screening for therapeutic and toxic effects to identify the most effective and less harmful therapy for the individual patient. 

References

Zhou, L., Zhang, C., Zhang, Y., & Shi, C. (2021). Application of organoid models in prostate cancer research. Frontiers in Oncology, 11, 736431.