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140-aa MUC1 repeats Circular RNA for Cancer Vaccine Research
CVAC-ORNA-0454
140-aa MUC1 repeats Circular RNA for Cancer Vaccine Research
Source：In vitro transcribed mRNA was further circularized to make this product as a circular RNA.
Alternative Names：Synthetic MUC1 Peptide Vaccine
Specification Sheet
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SKU：CVAC-ORNA-0454-LNP
Product Name：140-aa MUC1 repeats Circular RNA-LNP for Cancer Vaccine Research
Product Description：ALG-ORNA-0001 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU：CVAC-ORNA-0454
Product Name：140-aa MUC1 repeats Circular RNA for Cancer Vaccine Research
Product Description：In Vitro Transcribed mRNA template encoding 140-aa MUC1 repeats was further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
SKU：CVAC-ORNA-0454-LNP
Product Name：140-aa MUC1 repeats Circular RNA-LNP for Cancer Vaccine Research
Product Description：ALG-ORNA-0001 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU：CVAC-ORNA-0454
Product Name：140-aa MUC1 repeats Circular RNA for Cancer Vaccine Research
Product Description：In Vitro Transcribed mRNA template encoding 140-aa MUC1 repeats was further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
PROPERTIES
5'-UTR:
5' -untranslated region derived from human alpha-globin RNA with an optimized Kozak sequence
ORF:
140-aa MUC1 repeats
3'-UTR:
3' UTR comprising two sequence elements derived from the aminoterminal enhancer of split (AES) mRNA and the mitochondrial encoded 12S ribosomal RNA
Modifications:
N1-methyl-pseudouridine
Neutral Lipid:
1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)
Cholesterol:
Cholesterol
Lonizable Lipid:
1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (PEG2000-DMG)
PEG-lipid:
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)− 8-oxooctyl)amino)octanoate)(SM-102)
Storage:
-80 °C
Buffer:
PBS, pH7.5
Cryoprotectant:
Trehalose
Related Categories
mRNAs for Cancer Vaccine Research
Background

Gene Alias

Synthetic MUC1 Peptide Vaccine

Background

The 140-aa synthetic MUC1 peptide used for immunization corresponds to seven tandem repeats of a 20-aa sequence from the extracellular tandem repeat domain of MUC1. The amino acid sequence of one repeat is GVTSAPDTRPAPGSTAPPAH.

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