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Aed a 4 Circular RNA
Aed a 4 Circular RNA
ALG-ORNA-0027
Aed a 4 Circular RNA
Source:In vitro transcribed mRNA was further circularized to make this product as a circular RNA.
Alternative Names:alpha-glucosidase
SKU:ALG-ORNA-0027-LNP
Product Name:Aed a 4 Circular RNA-LNP
Product Description:ALG-ORNA-0027 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU:ALG-ORNA-0027
Product Name:Aed a 4 Circular RNA
Product Description:In Vitro Transcribed mRNA template encoding Aed a 4 was further circularized with Seattle Genova's Ostar technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
SKU:ALG-ORNA-0027-LNP
Product Name:Aed a 4 Circular RNA-LNP
Product Description:ALG-ORNA-0027 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU:ALG-ORNA-0027
Product Name:Aed a 4 Circular RNA
Product Description:In Vitro Transcribed mRNA template encoding Aed a 4 was further circularized with Seattle Genova's Ostar technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
PROPERTIES
ORF:
Aed a 4
Neutral Lipid:
1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)
Cholesterol:
Cholesterol
Lonizable Lipid:
1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (PEG2000-DMG)
PEG-lipid:
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)− 8-oxooctyl)amino)octanoate)(SM-102)
Storage:
-80 °C
Buffer:
PBS, pH7.31
Cryoprotectant:
Trehalose
Related Categories
mRNAs for Allergy Tolerization
Background

Gene Alias

alpha-glucosidase

Background

Allergenicity reference:PubMed:17620829‚PubMed:18220995‚PubMed:25661054 Route of allergen exposure:Injection; Subjects were allergic to mosquito bites. 13 of 13 were positive to challenge bites of mosquito, Aedes aegypti, 18 controls were negative. 6 of 13 subjects were IgE binding positive to recombinant Aed a 4 by ELISA, 18 controls were negative. ELISA and ELISA inhibition were performed with native (extract of head and thorax) and recombinant Aed a 4 produced in baculovirus insect cell line.

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