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Alt a 1 Circular RNA
Alt a 1 Circular RNA
ALG-ORNA-0039
Alt a 1 Circular RNA
Source:In vitro transcribed mRNA was further circularized to make this product as a circular RNA.
SKU:ALG-ORNA-0039-LNP
Product Name:Alt a 1 Circular RNA-LNP
Product Description:ALG-ORNA-0039 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU:ALG-ORNA-0039
Product Name:Alt a 1 Circular RNA
Product Description:In Vitro Transcribed mRNA template encoding Alt a 1 was further circularized with Seattle Genova's Ostar technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
SKU:ALG-ORNA-0039-LNP
Product Name:Alt a 1 Circular RNA-LNP
Product Description:ALG-ORNA-0039 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU:ALG-ORNA-0039
Product Name:Alt a 1 Circular RNA
Product Description:In Vitro Transcribed mRNA template encoding Alt a 1 was further circularized with Seattle Genova's Ostar technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
PROPERTIES
ORF:
Alt a 1
Neutral Lipid:
1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)
Cholesterol:
Cholesterol
Lonizable Lipid:
1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (PEG2000-DMG)
PEG-lipid:
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)− 8-oxooctyl)amino)octanoate)(SM-102)
Storage:
-80 °C
Buffer:
PBS, pH7.43
Cryoprotectant:
Trehalose
Related Categories
mRNAs for Allergy Tolerization
Background

Background

Allergenicity reference:PubMed:8957113 Route of allergen exposure:Airway; Allergenicity:- Of 57 sera from A. alternaria-sensitive patients, 46 (82%) showed IgE binding to rAlt a 1 on immunoblot. - IgE binding (serumpool, n=34) to A. alternaria extract in ELISA could be inhibited up to 70% by purified native Alt a 1: medline 22659252. - 6 out of 7 patients gave positive skin reactions in response to Alt a 1: medline 22097420 - IgE epitope mapping: medline 22555437

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