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Anti-idiotype MUC-1 mab Circular RNA for Cancer Vaccine Research
CVAC-ORNA-0056
Anti-idiotype MUC-1 mab Circular RNA for Cancer Vaccine Research
Source：In vitro transcribed mRNA was further circularized to make this product as a circular RNA.
Alternative Names：Anti-idiotype MUC-1 Monoclonal Antibody
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SKU：CVAC-ORNA-0056-LNP
Product Name：Anti-idiotype MUC-1 mab Circular RNA-LNP for Cancer Vaccine Research
Product Description：ALG-ORNA-0001 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU：CVAC-ORNA-0056
Product Name：Anti-idiotype MUC-1 mab Circular RNA for Cancer Vaccine Research
Product Description：In Vitro Transcribed mRNA template encoding Anti-idiotype MUC-1 mab was further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
SKU：CVAC-ORNA-0056-LNP
Product Name：Anti-idiotype MUC-1 mab Circular RNA-LNP for Cancer Vaccine Research
Product Description：ALG-ORNA-0001 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU：CVAC-ORNA-0056
Product Name：Anti-idiotype MUC-1 mab Circular RNA for Cancer Vaccine Research
Product Description：In Vitro Transcribed mRNA template encoding Anti-idiotype MUC-1 mab was further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
PROPERTIES
5'-UTR:
5' -untranslated region derived from human alpha-globin RNA with an optimized Kozak sequence
ORF:
Anti-idiotype MUC-1 mab
3'-UTR:
3' UTR comprising two sequence elements derived from the aminoterminal enhancer of split (AES) mRNA and the mitochondrial encoded 12S ribosomal RNA
Modifications:
N1-methyl-pseudouridine
Neutral Lipid:
1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)
Cholesterol:
Cholesterol
Lonizable Lipid:
1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (PEG2000-DMG)
PEG-lipid:
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)− 8-oxooctyl)amino)octanoate)(SM-102)
Storage:
-80 °C
Buffer:
PBS, pH7.5
Cryoprotectant:
Trehalose
Related Categories
mRNAs for Cancer Vaccine Research
Background

Gene Alias

Anti-idiotype MUC-1 Monoclonal Antibody

Background

Description: A monoclonal antibody that functionally mimics MUC-1 antigen, a tumor cell surface antigen. Administration of anti-idiotype MUC-1 monoclonal antibody may elicit an anti-idiotype antibody and corresponding T-cell response against MUC-1 expressing tumor cells. (NCIT_C2709).

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