Gene Accession
Q9UM73
Gene Alias
Protein names Recommended name ALK tyrosine kinase receptor Curated EC number EC:2.7.10.1 2 Publications (UniProtKB | ENZYME | Rhea) Alternative names Anaplastic lymphoma kinase 1 Publication CD Antigen Name CD246 Gene names Name ALK
Background
Alectinib (CH5424802, alecensa) is a potent and highly selective inhibitor of ALK tyrosine kinase with IC50 of 1.9 nM. More importantly, it has activity against L1196M which is one of the commonly seen secondary mutations in ALK gene leading to resistance to crizotinib.