Applications
Products
Service
Company
Gene Accession
Q9UM73
Gene Alias
Protein names Recommended name ALK tyrosine kinase receptor Curated EC number EC:2.7.10.1 2 Publications (UniProtKB | ENZYME | Rhea) Alternative names Anaplastic lymphoma kinase 1 Publication CD Antigen Name CD246 Gene names Name ALK
Background
Ceritinib effectively inhibits ALK harboring L1196M, G1269A, I1171T, and S1206Y mutations, and a cocrystal structure of ceritinib bound to ALK provides structural bases for this increased potency. Ceritinib is active in NSCLC cell lines with L1196M, G1269A, I1171T and S1206Y substitutions in ALK, which confer resistance to crizotinib.
