Gene Accession

P29276

Gene Alias

Protein names Recommended name Adenosine receptor A2a Gene names Name ADORA2A Synonyms ADORA4

Background

L702H mutation was reported in abiraterone- and enzalutamide-resistant patients receiving glucocorticoid treatment. This agrees with Lallous et al. functional studies, showing that L702H is the only single mutant activated by hydrocortisone. The T878A, H875Y and the L702H mutations have been observed in CRPC patients progressing during abiraterone treatment and associated with either the increased progesterone levels obtained after CYP17 inhibition or with the co-administration of exogenous glucocorticoids given to compensate for significantly reduced cortisol levels. The activating AR point mutations T877A, L702H and H875Y have been detected in cfDNA from patients with CRPC and shown to be associated with resistance to abiraterone and enzalutamide.