Gene Accession
P10398
Gene Alias
Protein names Recommended name Serine/threonine-protein kinase A-Raf EC number EC:2.7.11.1 (UniProtKB | ENZYME | Rhea) Alternative names Proto-oncogene A-Raf Proto-oncogene A-Raf-1 Proto-oncogene Pks Gene names Name ARAF Synonyms ARAF1, PKS, PKS2
Background
ARAF S214C has been found to be a recurrent oncogenic mutation in non-small cell lung cancer. It has been shown to confer sensitivity to sorafenib and trametenib in cell lines. In a case study of advanced stage lung adenocarcinoma harboring this mutation, sorafenib also acheived near-complete clinical remission. This case has brought more interest to the variant from a research and clinical perspective.