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Gene Accession
Q13535
Gene Alias
Protein names Recommended name Serine/threonine-protein kinase ATR EC number EC:2.7.11.1 (UniProtKB | ENZYME | Rhea) Alternative names Ataxia telangiectasia and Rad3-related protein FRAP-related protein 1 Gene names Name ATR Synonyms FRP1
Background
Deletion of ATR causes loss of DNA damage checkpoint responses and cell death; controls S-phase checkpoint. ATR deletion leads to hair graying, alopecia, kyphosis and osteoporosis. ATR deletion following TAM treatment leads to pervasive hair graying and patchy hair loss and kyphosis in ATRmKO mice. ATR deletion in postmitotic neurons does not compromise brain development and formation.
