Gene Accession

Q6W2J9

Gene Alias

Protein names Recommended name BCL-6 corepressor Short names BCoR Gene names Name BCOR Synonyms KIAA1575

Background

BCOR is a gene that encodes for an epigenetic regulator involved in the specification of cell differentiation and body structure development and takes part in the noncanonical polycomb repressive complex 1. BCOR mutations are found in aggressive B3-thymomas, adenoid cystic carcinoma, uterine corpus endometrial carcinoma, EBV + gastric carcinomas, colon and stomach adenocarcinoma, and lung tumors, regardless of histology. Loss-of-function mutations of BCOR are present in around 10% of unselected acute myeloid leukemia and myelodysplastic syndrome. BCOR internal tandem duplications (ITD) are present in more than 75% of CCSK, a pediatric renal sarcoma.