Gene Accession
P15056
Gene Alias
Protein names Recommended name Serine/threonine-protein kinase B-raf Curated EC number EC:2.7.11.1 2 Publications (UniProtKB | ENZYME | Rhea) Alternative names Proto-oncogene B-Raf p94 v-Raf murine sarcoma viral oncogene homolog B1 Gene names Name BRAF Imported Synonyms BRAF1, RAFB1
Background
L485-P490–deleted BRAF is an activating BRAF mutation, functions as a BRAF homodimer, and is able to transform the cells. Tumor cells with these BRAF deletions are resistant to the BRAF selective inhibitor vemurafenib but sensitive to the RAF dimer inhibitor LY3009120 in vitro and in vivo.