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Gene Accession
P51587
Gene Alias
Protein names Recommended name Breast cancer type 2 susceptibility protein Curated Alternative names Fanconi anemia group D1 protein Gene names Name BRCA2 Imported Synonyms FACD, FANCD1
Background
Both BRCA1 and BRCA2 proteins play a crucial role in the maintenance of genomic integrity through the process of precise DNA repair by homologous recombination. Mutations in BRCA1 and BRCA2 genes are associated with about 20% of familial breast and ovarian cancers.
