Gene Accession

Q16790

Gene Alias

Protein names Recommended name Carbonic anhydrase 9 EC number EC:4.2.1.1 6 Publications (UniProtKB | ENZYME | Rhea) Alternative names Carbonate dehydratase IX Carbonic anhydrase IX (CA-IX; CAIX) Membrane antigen MN P54/58N Renal cell carcinoma-associated antigen G250 (RCC-associated antigen G250) pMW1 Gene names Name CA9 Synonyms G250, MN

Background

Carbonic anhydrase IX (CA9/CA IX) is an enzyme that in humans is encoded by the CA9 gene. It is one of the 14 carbonic anhydrase isoforms found in humans and is a transmembrane dimeric metalloenzyme with an extracellular active site that facilitates acid secretion in the gastrointestinal tract. CA IX is overexpressed in many types of cancer including clear cell renal cell carcinoma (RCC) as well as carcinomas of the cervix, breast and lung where it promotes tumor growth by enhancing tumor acidosis.