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Gene Accession
P22681
Gene Alias
Protein names Recommended name E3 ubiquitin-protein ligase CBL EC number EC:2.3.2.27 3 Publications (UniProtKB | ENZYME | Rhea) Alternative names Casitas B-lineage lymphoma proto-oncogene Proto-oncogene c-Cbl RING finger protein 55 RING-type E3 ubiquitin transferase CBL Curated Signal transduction protein CBL Gene names Name CBL Synonyms CBL2, RNF55
Background
CBL Y371H lies within the linker region of the Cbl protein (PMID: 20622007). Y371H results in a loss of Cbl ubiquitin ligase activity, leading to activation of FLT3, AKT, and STAT5, and transformation of cultured cells when co-expressed with FLT3 or KIT (PMID: 23696637, PMID: 20622007).
