Gene Accession

P30281

Gene Alias

Protein names Recommended name G1/S-specific cyclin-D3 1 Publication Gene names Name CCND3 1 PublicationImported

Background

Cyclin D3 (CCND3) is a gene that encodes a protein that functions in the regulation of CDK kinases in the cell cycle. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, skin cancer, and stomach cancer. CCND3 is altered in 1.11% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, diffuse large B-cell lymphoma, not otherwise specified, and esophageal adenocarcinoma having the greatest prevalence of alterations. CCND3 Amplification is present in 0.59% of AACR GENIE cases, with breast invasive ductal carcinoma, lung adenocarcinoma, osteosarcoma, esophageal adenocarcinoma, and colon adenocarcinoma having the greatest prevalence.