Gene Accession

P24864

Gene Alias

Protein names Recommended name G1/S-specific cyclin-E1 Gene names Name CCNE1 Synonyms CCNE

Background

CCNE1 Amplification is present in 1.87% of AACR GENIE cases, with high grade ovarian serous adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, endometrial serous adenocarcinoma, and esophageal adenocarcinoma having the greatest prevalence. CCNE1 amplification has been identified as a primary oncogenic driver in a subset of high grade serous ovarian cancer that have an unmet clinical need. Amplification of the CCNE1 locus on chromosome 19q12 is prevalent in multiple tumour types, particularly in high-grade serous ovarian cancer, uterine tumours and gastro-oesophageal cancers, where high cyclin E levels are associated with genome instability, whole-genome doubling and resistance to cytotoxic and targeted therapies.