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CEACAM5/B7-1/ICAM-1/LFA-3 Circular RNA for Cancer Vaccine Research
CVAC-ORNA-0397
CEACAM5/B7-1/ICAM-1/LFA-3 Circular RNA for Cancer Vaccine Research
Source：In vitro transcribed mRNA was further circularized to make this product as a circular RNA.
Alternative Names：Recombinant Fowlpox-CEA(6D)/TRICOM Vaccine
Specification Sheet
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SKU：CVAC-ORNA-0397-LNP
Product Name：CEACAM5/B7-1/ICAM-1/LFA-3 Circular RNA-LNP for Cancer Vaccine Research
Product Description：ALG-ORNA-0001 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU：CVAC-ORNA-0397
Product Name：CEACAM5/B7-1/ICAM-1/LFA-3 Circular RNA for Cancer Vaccine Research
Product Description：In Vitro Transcribed mRNA template encoding CEACAM5/B7-1/ICAM-1/LFA-3 was further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
SKU：CVAC-ORNA-0397-LNP
Product Name：CEACAM5/B7-1/ICAM-1/LFA-3 Circular RNA-LNP for Cancer Vaccine Research
Product Description：ALG-ORNA-0001 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU：CVAC-ORNA-0397
Product Name：CEACAM5/B7-1/ICAM-1/LFA-3 Circular RNA for Cancer Vaccine Research
Product Description：In Vitro Transcribed mRNA template encoding CEACAM5/B7-1/ICAM-1/LFA-3 was further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
PROPERTIES
5'-UTR:
5' -untranslated region derived from human alpha-globin RNA with an optimized Kozak sequence
ORF:
CEACAM5/B7-1/ICAM-1/LFA-3
3'-UTR:
3' UTR comprising two sequence elements derived from the aminoterminal enhancer of split (AES) mRNA and the mitochondrial encoded 12S ribosomal RNA
Modifications:
N1-methyl-pseudouridine
Neutral Lipid:
1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)
Cholesterol:
Cholesterol
Lonizable Lipid:
1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (PEG2000-DMG)
PEG-lipid:
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)− 8-oxooctyl)amino)octanoate)(SM-102)
Storage:
-80 °C
Buffer:
PBS, pH7.5
Cryoprotectant:
Trehalose
Related Categories
mRNAs for Cancer Vaccine Research
Background

Gene Alias

Recombinant Fowlpox-CEA(6D)/TRICOM Vaccine

Background

Description: A cancer vaccine comprised of a recombinant fowlpox virus vector encoding the carcinoembryonic antigen (CEA) and a TRIad of COstimulatory Molecules (B7-1, ICAM-1 and LFA-3) (TRICOM). This agent may enhance CEA presentation to antigen presenting cells (APC) and activate cytotoxic T-cells against CEA-expressing tumors. (NCI04) (NCIT_C2620).

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