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Background
FKBP-CASP8 protein is a chimeric protein composed of the binding domain of FK506-binding protein (FKBP) and the protease domain of CASP8. The previous report showed that conversion to the active form by autoprocessing occurs only when this molecule is dimerized by a synthetic divalent FKBP ligand. This property excludes the possibility of autoactivation by self-oligomerization.
