Background

GSC (Goosecoid Homeobox) is a Protein Coding gene. Diseases associated with GSC include Short Stature, Auditory Canal Atresia, Mandibular Hypoplasia, And Skeletal Abnormalities and Fraser Syndrome 1. Among its related pathways are Gastrulation and Nervous system development. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and RNA polymerase II-specific DNA-binding transcription factor binding. An important paralog of this gene is GSC2. Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals. ( GSC_HUMAN,P56915 )