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gp100/tyrosinase/MLANA Circular RNA for Cancer Vaccine Research
CVAC-ORNA-0453
gp100/tyrosinase/MLANA Circular RNA for Cancer Vaccine Research
Source:In vitro transcribed mRNA was further circularized to make this product as a circular RNA.
Alternative Names:Synthetic Melanoma-Associated Antigens Vaccine
SKU:CVAC-ORNA-0453-LNP
Product Name:gp100/tyrosinase/MLANA Circular RNA-LNP for Cancer Vaccine Research
Product Description:ALG-ORNA-0001 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU:CVAC-ORNA-0453
Product Name:gp100/tyrosinase/MLANA Circular RNA for Cancer Vaccine Research
Product Description:In Vitro Transcribed mRNA template encoding gp100/tyrosinase/MLANA was further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
SKU:CVAC-ORNA-0453-LNP
Product Name:gp100/tyrosinase/MLANA Circular RNA-LNP for Cancer Vaccine Research
Product Description:ALG-ORNA-0001 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU:CVAC-ORNA-0453
Product Name:gp100/tyrosinase/MLANA Circular RNA for Cancer Vaccine Research
Product Description:In Vitro Transcribed mRNA template encoding gp100/tyrosinase/MLANA was further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
PROPERTIES
5'-UTR:
5' -untranslated region derived from human alpha-globin RNA with an optimized Kozak sequence
ORF:
gp100/tyrosinase/MLANA
3'-UTR:
3' UTR comprising two sequence elements derived from the aminoterminal enhancer of split (AES) mRNA and the mitochondrial encoded 12S ribosomal RNA
Modifications:
N1-methyl-pseudouridine
Neutral Lipid:
1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)
Cholesterol:
Cholesterol
Lonizable Lipid:
1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (PEG2000-DMG)
PEG-lipid:
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)− 8-oxooctyl)amino)octanoate)(SM-102)
Storage:
-80 °C
Buffer:
PBS, pH7.5
Cryoprotectant:
Trehalose
Background

Gene Alias

Synthetic Melanoma-Associated Antigens Vaccine

Background

Description: A cancer vaccine containing synthetic epitope peptides derived from melanoma tumor-associated antigens (TAAs), including melanoma-melanocyte antigen gp100(280-288), melanoma-associated antigen tyrosinase(1-9), and melanoma-associated antigen melan-A(27-35). Upon administration, synthetic melanoma-associated antigens vaccine may stimulate a cytotoxic T-lymphocyte immune response against melanoma cells that express TAAs which share epitopes with the vaccine epitope peptides, resulting in tumor cell lysis. (NCIT_C48639).

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