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Background
Inducible Caspase9 (iCasp9) is a cellular suicide gene that allows conditional cell elimination. It comprises a human Caspase9 fused with an inducer-binding domain which could be dimerized by the Chemical Inducer of Dimerization (CID), AP20187, or AP1903. iCasp9 is dimerized and activated by induced proximity of the inducer-binding domain, leading to activation of the apoptosis pathway. Due to the efficient induction of cell death, iCasp9 has been used as one of the most promising killing strategies in cancer therapies and adoptive cell therapies.
