Background

KLF2 (KLF Transcription Factor 2) is a Protein Coding gene. Diseases associated with KLF2 include Cerebral Cavernous Malformations and Spleen Cancer. Among its related pathways are White fat cell differentiation and EV release from cardiac cells and their functional effects. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is KLF4. Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504). Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758). ( KLF2_HUMAN,Q9Y5W3 )