Background

MIXL1 (Mix Paired-Like Homeobox) is a Protein Coding gene. Diseases associated with MIXL1 include Fanconi Anemia, Complementation Group F and Germ Cell And Embryonal Cancer. Among its related pathways are Gastrulation and Nervous system development. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is PROP1. Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity). ( MIXL1_HUMAN,Q9H2W2 )