Background

MTF2 (Metal Response Element Binding Transcription Factor 2) is a Protein Coding gene. Diseases associated with MTF2 include Non-Syndromic X-Linked Intellectual Disability 14 and Retinitis Pigmentosa 48. Among its related pathways are RNA Polymerase I Promoter Opening and Gene expression (Transcription). Gene Ontology (GO) annotations related to this gene include methylated histone binding. An important paralog of this gene is PHF19. Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, 23228662, 31959557). Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity). Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity). Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity). In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity). Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). ( MTF2_HUMAN,Q9Y483 )