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MUC1/B7-1/ICAM-1/LFA-3 Circular RNA for Cancer Vaccine Research
CVAC-ORNA-0431
MUC1/B7-1/ICAM-1/LFA-3 Circular RNA for Cancer Vaccine Research
Source:In vitro transcribed mRNA was further circularized to make this product as a circular RNA.
Alternative Names:rF-MUC1(DF3)/TRICOM Vaccine
SKU:CVAC-ORNA-0431-LNP
Product Name:MUC1/B7-1/ICAM-1/LFA-3 Circular RNA-LNP for Cancer Vaccine Research
Product Description:ALG-ORNA-0001 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU:CVAC-ORNA-0431
Product Name:MUC1/B7-1/ICAM-1/LFA-3 Circular RNA for Cancer Vaccine Research
Product Description:In Vitro Transcribed mRNA template encoding MUC1/B7-1/ICAM-1/LFA-3 was further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
SKU:CVAC-ORNA-0431-LNP
Product Name:MUC1/B7-1/ICAM-1/LFA-3 Circular RNA-LNP for Cancer Vaccine Research
Product Description:ALG-ORNA-0001 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU:CVAC-ORNA-0431
Product Name:MUC1/B7-1/ICAM-1/LFA-3 Circular RNA for Cancer Vaccine Research
Product Description:In Vitro Transcribed mRNA template encoding MUC1/B7-1/ICAM-1/LFA-3 was further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
PROPERTIES
5'-UTR:
5' -untranslated region derived from human alpha-globin RNA with an optimized Kozak sequence
ORF:
MUC1/B7-1/ICAM-1/LFA-3
3'-UTR:
3' UTR comprising two sequence elements derived from the aminoterminal enhancer of split (AES) mRNA and the mitochondrial encoded 12S ribosomal RNA
Modifications:
N1-methyl-pseudouridine
Neutral Lipid:
1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)
Cholesterol:
Cholesterol
Lonizable Lipid:
1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (PEG2000-DMG)
PEG-lipid:
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)− 8-oxooctyl)amino)octanoate)(SM-102)
Storage:
-80 °C
Buffer:
PBS, pH7.5
Cryoprotectant:
Trehalose
Background

Gene Alias

rF-MUC1(DF3)/TRICOM Vaccine

Background

Description: A fowlpox vaccine containing the tumor-associated antigen mucin-1 (MUC1), found in pancreatic tumor cells, and a TRIad of COstimulatory Molecules (B7-1, ICAM-1 and LFA-3; TRICOM), which is designed to enhance antigen presentation and activation of immune responses critical for tumor destruction. Vaccination with this agent may elicit a host immune response against MUC1-expressing tumor cells. (NCIT_C29558).

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