Background

POU5F1 (POU Class 5 Homeobox 1) is a Protein Coding gene. Diseases associated with POU5F1 include Embryonal Carcinoma and Germinoma. Among its related pathways are Human Early Embryo Development and Gastrulation. Gene Ontology (GO) annotations related to this gene include RNA binding and sequence-specific DNA binding. An important paralog of this gene is POU5F1B. Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. ( PO5F1_HUMAN,Q01860 )