Background

PRDM14 (PR/SET Domain 14) is a Protein Coding gene. Diseases associated with PRDM14 include Malignant Pineal Area Germ Cell Neoplasm and Brain Germinoma. Among its related pathways are Nervous system development and Endoderm differentiation. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is PRDM1. Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'. ( PRD14_HUMAN,Q9GZV8 )