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SARS-CoV-2 9b Protein Circular RNA
VAC-RNA-012
SARS-CoV-2 9b Protein Circular RNA
Source:In vitro transcribed mRNA was further circularized to make this product as a circular RNA.
Alternative Names:ORF9b protein (ORF9b) (Accessory protein 9b) (ORF-9b) (Protein 9b)
SKU:VAC-RNA-012-LNP
Product Name:SARS-CoV-2 9b Protein Circular RNA-LNP
Product Description:VAC-RNA-012 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU:VAC-RNA-012
Product Name:SARS-CoV-2 9b Protein Circular RNA
Product Description:In Vitro Transcribed mRNA template encoding SARS-CoV-2 9b Protein Circular RNAwas further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
SKU:VAC-RNA-012-LNP
Product Name:SARS-CoV-2 9b Protein Circular RNA-LNP
Product Description:VAC-RNA-012 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU:VAC-RNA-012
Product Name:SARS-CoV-2 9b Protein Circular RNA
Product Description:In Vitro Transcribed mRNA template encoding SARS-CoV-2 9b Protein Circular RNAwas further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
PROPERTIES
ORF:
=A13
Modifications:
N1-methyl-pseudouridine
Neutral Lipid:
1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)
Cholesterol:
Cholesterol
Lonizable Lipid:
1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (PEG2000-DMG)
PEG-lipid:
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)− 8-oxooctyl)amino)octanoate)(SM-102)
Storage:
-80 °C
Buffer:
PBS, pH7.15
Cryoprotectant:
Trehalose
Related Categories
mRNAs for Vaccine Development
Background

Gene Accession

P0DTD2

Gene Alias

ORF9b protein (ORF9b) (Accessory protein 9b) (ORF-9b) (Protein 9b)

Background

FUNCTION: Plays a role in inhibiting the host innate immune response by targeting the mitochondrial-associated innate immune response. Acts by binding to host TOMM70, inhibiting its binding to HSP90AB1 thereby disrupting the interferon activation pathway. {ECO:0000269|PubMed:32728199, ECO:0000269|PubMed:34502139}.

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