Background

SOX3 (SRY-Box Transcription Factor 3) is a Protein Coding gene. Diseases associated with SOX3 include Intellectual Developmental Disorder, X-Linked, With Panhypopituitarism and Panhypopituitarism, X-Linked. Among its related pathways are Signaling by WNT and ERK Signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is SOX1. Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). ( SOX3_HUMAN,P41225 )