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super cytosine deaminase (SCD) Circular RNA for Cancer Vaccine Research
CVAC-ORNA-0435
super cytosine deaminase (SCD) Circular RNA for Cancer Vaccine Research
Source：In vitro transcribed mRNA was further circularized to make this product as a circular RNA.
Alternative Names：rMeV- SCD
Specification Sheet
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SKU：CVAC-ORNA-0435-LNP
Product Name：super cytosine deaminase (SCD) Circular RNA-LNP for Cancer Vaccine Research
Product Description：ALG-ORNA-0001 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU：CVAC-ORNA-0435
Product Name：super cytosine deaminase (SCD) Circular RNA for Cancer Vaccine Research
Product Description：In Vitro Transcribed mRNA template encoding super cytosine deaminase (SCD) was further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
SKU：CVAC-ORNA-0435-LNP
Product Name：super cytosine deaminase (SCD) Circular RNA-LNP for Cancer Vaccine Research
Product Description：ALG-ORNA-0001 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU：CVAC-ORNA-0435
Product Name：super cytosine deaminase (SCD) Circular RNA for Cancer Vaccine Research
Product Description：In Vitro Transcribed mRNA template encoding super cytosine deaminase (SCD) was further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
PROPERTIES
5'-UTR:
5' -untranslated region derived from human alpha-globin RNA with an optimized Kozak sequence
ORF:
super cytosine deaminase (SCD)
3'-UTR:
3' UTR comprising two sequence elements derived from the aminoterminal enhancer of split (AES) mRNA and the mitochondrial encoded 12S ribosomal RNA
Modifications:
N1-methyl-pseudouridine
Neutral Lipid:
1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)
Cholesterol:
Cholesterol
Lonizable Lipid:
1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (PEG2000-DMG)
PEG-lipid:
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)− 8-oxooctyl)amino)octanoate)(SM-102)
Storage:
-80 °C
Buffer:
PBS, pH7.5
Cryoprotectant:
Trehalose
Related Categories
mRNAs for Cancer Vaccine Research
Background

Gene Alias

rMeV- SCD

Background

Preparation: A measles vaccine virus (MeV) vector expressing super cytosine deaminase (SCD), a fusion protein of yeast cytosine deaminase and uracil phosphoribosyltransferase (Lange et al., 2013).

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