Background
SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit) is a Protein Coding gene. Diseases associated with SUZ12 include Imagawa-Matsumoto Syndrome and Endometrial Stromal Sarcoma. Among its related pathways are RNA Polymerase I Promoter Opening and PIP3 activates AKT signaling. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and chromatin binding. Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, 15231737, 15385962, 16618801, 17344414, 18285464, 28229514, 29499137, 31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12435631, 12351676, 15385962, 15099518, 15225548, 15684044, 16431907, 18086877, 18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, 16618801, 17200670, 31959557). ( SUZ12_HUMAN,Q15022 )