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VHL2 (Y12M) Circular RNA for Cancer Vaccine Research
CVAC-ORNA-0485
VHL2 (Y12M) Circular RNA for Cancer Vaccine Research
Source:In vitro transcribed mRNA was further circularized to make this product as a circular RNA.
Alternative Names:VHL2 (Y12M) Peptide
SKU:CVAC-ORNA-0485-LNP
Product Name:VHL2 (Y12M) Circular RNA-LNP for Cancer Vaccine Research
Product Description:ALG-ORNA-0001 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU:CVAC-ORNA-0485
Product Name:VHL2 (Y12M) Circular RNA for Cancer Vaccine Research
Product Description:In Vitro Transcribed mRNA template encoding VHL2 (Y12M) was further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
SKU:CVAC-ORNA-0485-LNP
Product Name:VHL2 (Y12M) Circular RNA-LNP for Cancer Vaccine Research
Product Description:ALG-ORNA-0001 was encapsulated with lipid nanoparticles through Seattle Genova's LipoX platform.
SKU:CVAC-ORNA-0485
Product Name:VHL2 (Y12M) Circular RNA for Cancer Vaccine Research
Product Description:In Vitro Transcribed mRNA template encoding VHL2 (Y12M) was further circularized with Seattle Genova's OSTAR technology. The resulting circRNAs are very stable and have low immunogenicity enabling prolonged protein translation in different cells without cellular toxicity.
PROPERTIES
5'-UTR:
5' -untranslated region derived from human alpha-globin RNA with an optimized Kozak sequence
ORF:
VHL2 (Y12M)
3'-UTR:
3' UTR comprising two sequence elements derived from the aminoterminal enhancer of split (AES) mRNA and the mitochondrial encoded 12S ribosomal RNA
Modifications:
N1-methyl-pseudouridine
Neutral Lipid:
1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)
Cholesterol:
Cholesterol
Lonizable Lipid:
1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (PEG2000-DMG)
PEG-lipid:
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)− 8-oxooctyl)amino)octanoate)(SM-102)
Storage:
-80 °C
Buffer:
PBS, pH7.5
Cryoprotectant:
Trehalose
Background

Gene Alias

VHL2 (Y12M) Peptide

Background

Description: A peptide vaccine derived from the von Hippel-Lindau (VHL) tumor suppressor protein, a general transcription factor. VHL2 (Y12M) peptide is a point mutation variant (from tyrosine to methionine at amino acid position 12) of the VHL protein. Vaccination with this peptide may stimulate a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing this VHL mutant protein. (NCIT_C2824).

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